Beverly Hills · Century City
M.D., F.A.C.S. — Facial Plastic Surgery
“All-natural autologous regenerative treatment for skin renewal and volume restoration”
PRF (Platelet-Rich Fibrin) is an advanced regenerative injectable derived entirely from the patient's own blood — with no additives, synthetics, or foreign substances. Unlike earlier platelet therapies, PRF is processed without anticoagulants, producing a fibrin matrix rich in growth factors, white blood cells, and stem cell precursors that release their regenerative signals slowly over time. This natural, gradual delivery makes PRF one of the most biologically harmonious skin rejuvenation options available.
Treatment Overview
Session Time
Treatment takes approximately 60 minutes including blood draw and preparation time. Topical numbing is applied before injection. No anesthesia is required.
Downtime
Mild redness and possible injection-site bruising for 24–48 hours. Most patients return to normal activities the same or following day. Strenuous activity should be avoided for 24 hours after treatment.
Results Timeline
Results are gradual and develop over 4–8 weeks as collagen remodeling progresses. A series of 3–4 sessions spaced 4–6 weeks apart is typically recommended for optimal outcomes. Improvement in skin quality continues for several months after the final session.
Performing Physician
Carlo Honrado, M.D., F.A.C.S.
Beverly Hills · Century City
PRF may address under-eye hollowing and dark circles, fine lines and early wrinkles, acne scarring and uneven skin texture, skin laxity and loss of firmness, thinning skin, and hyperpigmentation. The growth factors within PRF stimulate fibroblast activity, trigger new collagen and elastin production, enhance local circulation, and support the skin's natural regenerative capacity. Because PRF uses the patient's own biology, results develop gradually and naturally — enhancing the face rather than altering it.
A small amount of blood is drawn and centrifuged at a slower speed than traditional PRP preparation, which preserves a higher concentration of platelets, fibrin, and white blood cells. The resulting fibrin matrix is drawn up and injected into targeted facial areas. The fibrin scaffold acts as a natural depot, slowly releasing growth factors over days to weeks — a key advantage over PRP, which releases its signals rapidly. The slow-release mechanism supports more sustained collagen induction and tissue remodeling.
Consultation
Dr. Honrado evaluates facial anatomy, skin quality, and treatment goals to determine the appropriate injection zones and session plan.
Blood Draw
A small amount of blood is drawn from the arm — identical to a standard lab draw.
Centrifugation
The blood is centrifuged at a controlled speed to separate and concentrate the platelet-rich fibrin matrix.
Topical Numbing
Numbing cream is applied to the treatment areas to minimize discomfort during injection.
Injection
PRF is injected into targeted facial areas using fine needles, with placement guided by anatomical assessment.
Post-Treatment
Patients are advised to avoid vigorous exercise, excessive heat, and direct sun for 24 hours. A gentle skincare routine is recommended during healing.
Next Step
A formal consultation with Dr. Honrado allows for personalized assessment of your anatomy and goals.
Book a ConsultationContent reviewed by Carlo Honrado, M.D., F.A.C.S. · 2026-05-16
