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Beverly Hills  ·  Century City

Dr. Carlo Honrado

M.D., F.A.C.S.  —  Facial Plastic Surgery

HomeTreatmentsPRF — Platelet Rich Fibrin
Regenerative Injectables

PRF — Platelet Rich Fibrin

All-natural autologous regenerative treatment for skin renewal and volume restoration

PRF (Platelet-Rich Fibrin) is an advanced regenerative injectable derived entirely from the patient's own blood — with no additives, synthetics, or foreign substances. Unlike earlier platelet therapies, PRF is processed without anticoagulants, producing a fibrin matrix rich in growth factors, white blood cells, and stem cell precursors that release their regenerative signals slowly over time. This natural, gradual delivery makes PRF one of the most biologically harmonious skin rejuvenation options available.

Treatment Overview

Session Time

Treatment takes approximately 60 minutes including blood draw and preparation time. Topical numbing is applied before injection. No anesthesia is required.

Downtime

Mild redness and possible injection-site bruising for 24–48 hours. Most patients return to normal activities the same or following day. Strenuous activity should be avoided for 24 hours after treatment.

Results Timeline

Results are gradual and develop over 4–8 weeks as collagen remodeling progresses. A series of 3–4 sessions spaced 4–6 weeks apart is typically recommended for optimal outcomes. Improvement in skin quality continues for several months after the final session.

Performing Physician

Carlo Honrado, M.D., F.A.C.S.

Beverly Hills · Century City

What It Does

PRF may address under-eye hollowing and dark circles, fine lines and early wrinkles, acne scarring and uneven skin texture, skin laxity and loss of firmness, thinning skin, and hyperpigmentation. The growth factors within PRF stimulate fibroblast activity, trigger new collagen and elastin production, enhance local circulation, and support the skin's natural regenerative capacity. Because PRF uses the patient's own biology, results develop gradually and naturally — enhancing the face rather than altering it.

How It Works

A small amount of blood is drawn and centrifuged at a slower speed than traditional PRP preparation, which preserves a higher concentration of platelets, fibrin, and white blood cells. The resulting fibrin matrix is drawn up and injected into targeted facial areas. The fibrin scaffold acts as a natural depot, slowly releasing growth factors over days to weeks — a key advantage over PRP, which releases its signals rapidly. The slow-release mechanism supports more sustained collagen induction and tissue remodeling.

Concerns Addressed

What PRF — Platelet Rich Fibrin May Address

Under-eye hollowing (tear trough)
Fine lines and early surface wrinkles
Acne scars and skin texture irregularities
Mild facial volume loss
Skin laxity and crepiness
Dull, thinning, or devitalized skin
Hyperpigmentation
Overall skin quality and radiance
The Process

What to Expect

1

Consultation

Dr. Honrado evaluates facial anatomy, skin quality, and treatment goals to determine the appropriate injection zones and session plan.

2

Blood Draw

A small amount of blood is drawn from the arm — identical to a standard lab draw.

3

Centrifugation

The blood is centrifuged at a controlled speed to separate and concentrate the platelet-rich fibrin matrix.

4

Topical Numbing

Numbing cream is applied to the treatment areas to minimize discomfort during injection.

5

Injection

PRF is injected into targeted facial areas using fine needles, with placement guided by anatomical assessment.

6

Post-Treatment

Patients are advised to avoid vigorous exercise, excessive heat, and direct sun for 24 hours. A gentle skincare routine is recommended during healing.

FAQs

Frequently Asked Questions

Explore

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Next Step

Ready to learn if PRF — Platelet Rich Fibrin is right for you?

A formal consultation with Dr. Honrado allows for personalized assessment of your anatomy and goals.

Book a Consultation

Content reviewed by Carlo Honrado, M.D., F.A.C.S.  ·  2026-05-16

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